Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. TLDR: Build the model backbone for the next era of AI-powered spatial biology. Please include a cover letter with your application detailing your qualifications and experience for this position. Describe a deep learning project you have executed—ideally a creative use of a vision transformer, U-Net architecture, or Diffusion model that you trained yourself. Projects in computer vision for microscopy image analysis are especially relevant. Include a link to a code repository if possible. If you contributed to a joint project, please describe your specific contributions. Briefly discuss the project's results, limitations, and challenges you encountered. Finally, include a link to your GitHub profile, personal website, or similar and/ or any relevant projects at the bottom of your cover letter. About the role: AI@HHMI: HHMI is investing $500 million over the next 10 years to support AI-driven projects and to embed AI systems throughout every stage of the scientific process in labs across HHMI. The Foundational Microscopy Image Analysis (MIA) project sits at the heart of AI@HHMI. Our ambition is big: to create one of the world’s most comprehensive, multimodal 3D/4D microscopy datasets and use it to power a vision foundation model capable of accelerating discovery across the life sciences. We are seeking a highly skilled AI Research Engineer to join our team and advance our AI-driven scientific initiatives. You will develop and deploy a self-supervised pre-training pipeline for learning from a large-scale microscopy dataset. You will work with expert computational scientists, data engineers, and experimentalists to train models that learn foundational embeddings that can be used across a wide range of microscopy modalities and applications. In collaboration with other engineers and scientists, you will use these models for scalable vision tasks, instance segmentation, tracking, classification, and more. You will utilize probabilistic models to produce uncertainty-aware predictions across scales. This role requires deep knowledge of the underlying models and practical implementation skills to maximize biological impact. You will lead rigorous model evaluations, implement novel architectures, and ensure all work meets the highest standards of reproducible open science. Success in this role requires close collaboration with our microscopy experts, cellular biologists, neuroscientists, and computer scientists to ensure models can be deployed in large data real-world scenarios. Strong programming skills in Python, PyTorch, and/ or JAX are required, along with the ability to reason about neural network behavior from first principles. The role also requires knowledge of microscopy data formats and tools such as Zarr and Neuroglancer. We seek candidates who can think critically about model design, understand how architectural choices and regularization affect model behavior, and design rigorous experiments to evaluate models. Domain expertise in microscopy image analysis is not necessary, but will be highly valued. Because this is a team project, we value a clean shared codebase and git-based collaborative workflows. Familiarity with state-of-the-art vision frameworks such as DinoV3, SAM, CellPose, or Vision Transformers is required. We are looking for candidates with experience in ML model deployment, workflow orchestration, and high-throughput data processing, as well as experience working with large biological datasets in scalable GPU-based computing environments. What we provide: A competitive compensation package, with comprehensive health and welfare benefits. A supportive team environment that promotes collaboration and knowledge sharing. Access to a world-class computational infrastructure and high-quality datasets. The opportunity to engage with world-class researchers, software engineers, and AI/ML experts, contribute to impactful science, and be part of a dynamic community committed to advancing humanity’s understanding of fundamental scientific questions. Amenities that enhance work-life balance, such as on-site childcare, free gyms, available on-campus housing, social and dining spaces, and convenient shuttle bus service to Janelia from the Washington D.C. metro area. Opportunity to partner with frontier AI labs on scientific applications of AI (see https://www.anthropic.com/news/anthropic-partners-with-allen-institute-and-howard-hughes-medical-institute). What you’ll do: Research and explore the model design space for vision foundation models of multi-modal biological microscopy data. Build a self-supervised pre-training pipeline on a large-scale foundational dataset of multi-modal biological microscopy data. Design and execute rigorous experiments to evaluate model performance on a wide distribution of microscopy images and model architectures. Collaborate with interdisciplinary teams, potentially mentor junior engineers, and direct or assist in directing the work of others to meet project goals while advising stakeholders on data strategies and best practices. Deploy models both at Janelia and in the broader scientific community and ensure downstream usability. What you bring: Master's or PhD degree in Computer Science, Applied Mathematics, Computational Neuroscience, or a related field—or an equivalent combination of education and relevant experience. 3+ years of experience training and evaluating deep learning architectures such as Transformers or U-Nets, particularly on image or point cloud data. Strong programming skills in Python, PyTorch, and JAX. Skills in Javascript are a plus. Familiarity with computational tools in microscopy and connectomics data (Cellpose, CAVE, Flood Filling Networks, Neuroglancer, Zarr). Familiarity with state of the art (self-supervised) computer vision algorithms (e.g., DINO, Masked Autoencoders, SAM). Experience with ML model deployment, workflow orchestration, and high-throughput data processing and model training. Keen interest to work in a truly interdisciplinary environment and learn about cellular/molecular biology (e.g. transcriptomics) & neuroscience. Physical Requirements: Remaining in a normal seated or standing position for extended periods of time; reaching and grasping by extending hand(s) or arm(s); dexterity to manipulate objects with fingers, for example using a keyboard; communication skills using the spoken word; ability to see and hear within normal parameters; ability to move about workspace. The position requires mobility, including the ability to move materials weighing up to several pounds (such as a laptop computer or tablet). Persons with disabilities may be able to perform the essential duties of this position with reasonable accommodation. Requests for reasonable accommodation will be evaluated on an individual basis. Please Note: This job description sets forth the job’s principal duties, responsibilities, and requirements; it should not be construed as an exhaustive statement, however. Unless they begin with the word “may,” the Essential Duties and Responsibilities described above are “essential functions” of the job, as defined by the Americans with Disabilities Act. Compensation Range AI Engineer I: $96,325.60 (minimum) - $120,407.00 (midpoint) - $156,529.10 (maximum) AI Engineer II: $123,125.60 (minimum) - $153,907.00 (midpoint) - $200,079.10 (maximum) AI Engineer III: $149,515.20 (minimum) - $186,894.00 (midpoint) - $242,962.20 (maximum) AI Engineer IV: $184,453.60 (minimum) - $230,567.00 (midpoint) - $299,737.10 (maximum) Pay Type: Salary HHMI’s salary structure is developed based on relevant job market data. HHMI considers a candidate's education, previous experiences, knowledge, skills and abilities, as well as internal consistency when making job offers. Typically, a new hire for this position in this location is compensated between the minimum and the midpoint of the salary range. #LI-BG1 Compensation and Benefits Our employees are compensated from a total rewards perspective in many ways for their contributions to our mission, including competitive pay, exceptional health benefits, retirement plans, time off, and a range of recognition and wellness programs. Visit our Benefits at HHMI site to learn more. HHMI is an Equal Opportunity Employer We use E-Verify to confirm the identity and employment eligibility of all new hires. Howard Hughes Medical Institute (HHMI) is an independent, ever-evolving philanthropy that supports basic biomedical scientists and educators with the potential for transformative impact. We make long-term investments in people, not just projects, because we believe in the power of individuals to make breakthroughs over time. 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